About my academic career
Born and raised in: 
currently working at: 
B.Sc in applied Chemistry @ ECNU, China
M.Sc in organic Chemistry @ ECNU, China
Master thesis: Multicomponent CO insertion reactions of Phenol
PhD candidate @ Johnson&Johnson Innovative Medicine, Belgium
PhD thesis: Flow electrochemical cross-coupling as a new tool for drug discovery
Harnessing the Intrinsic Reactivity of 2‐Cyano‐Substituted Heteroarenes to Achieve Programmable Double Alkylation
Z. Sun, J. Zhao, H. Deng, L. Tian, B. Tang, K. -C. Liu, H. Y. Zhu. Adv. Synth. Catal. 2020, 362, 1502.
Direct photochemical cross-coupling between aliphatic acids and BF3K salts
Z. Sun, B. Tang, K. -C. Liu, H. Y. Zhu. Chem. Commun. 2020, 56, 1294.
Collective Synthesis of Phenanthridinone through C-H Activation Involving a Pd-Catalyzed Aryne Multicomponent Reaction
M. Feng, B. Tang, H. Xu, X. Jiang, Org. Lett. 2016, 18, 4352.
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
M. Feng, B. Tang, S. Liang, X. Jiang, Current Topics in Medicinal Chemistry. 2016, 16, 1200.
Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids
M. Feng, B. Tang, N. Wang, H. Xu, X. Jiang, Angew. Chem. Int. Ed. 2015, 54, 14960.
Recent advances of desymmetrization protocol applied in natural product total synthesis
M. Wang, M. Feng, B. Tang, X. Jiang, Tetrahedron Lett. 2014, 70, 7147.
Fused heterocyclic derivatives.
WO/2022/253255, Filed Jan 6, 2022.
C. Lu, G. Deng, L. Liu, X. Li, Z. Liu, B. Tang, W, Cai, S. Plunkett, P. Pye, L. Deratt, P. Raboisson, E. Jacoby, S. Grosse, Z. Cheng, K. Vandyck, T. Jonkers, S. Kuduk.
Fused heterocyclic derivatives.
WO/2022/253259, Filed Jan 6, 2022.
C. Lu, X. Li, L. Liu, G. Deng, Z. Liu, B. Tang, W, Cai, Z. Cheng, S. Grosse, K. Vandyck, E. Jacoby, T. Jonkers, P. Raboisson, S. Kuduk, L. Deratt.
Fused heterocyclic derivatives and their use in the treatment of HBV infection.
WO/2022/116997, Filed Jan 12, 2021.
L. Liu, G. Deng, C. Lu, B. Tang, Z. Liu, Z. Cheng, S. Grosse, K. Vandyck, E. Jacoby, T. Jonkers, P. Raboisson, S. Kuduk, L. Deratt.
Fused heterocyclic derivatives and their use in the treatment of HBV infection.
WO/2022/116999, Filed Jan 12, 2021.
L. Liu, G. Deng, C. Lu, B. Tang, Z. Liu, K. Vandyck, S. Grosse, T. Jonkers, E. Jacoby, S. Kuduk, P. Raboisson, L. Deratt.
KRAS Inhibitors for treatment of cancers.
WO/2022/095960, Filed May 11, 2021.
E. Shang, B. Zhong, T. Zhang, G. Song, R. Wang, B. Tang, X. Hu.
About my thesis - Flow electrochemical cross-coupling as a new tool for drug discovery
Organic electrosynthesis is an eco-friendly and cost-effective approach, which can realize redox transformation via anodic oxidation and cathodic reduction, avoiding the use of stoichiometric amounts of hazardous redox chemicals that could harm the environment.
This project aims to develop novel electrochemical methodologies to expand the toolbox of reactions available for medicinal chemists for molecular editing, selective functionalization of biomolecules and direct synthesis of drug metabolites. Our approach involves combining batch and flow electrochemistry technologies to support high conversion and selectivity synthesis while also enabling rapid products formation. The methods will have a specific focus on the direct applications in ongoing medicinal chemistry projects, as well as progress towards a more environmentally friendly pharmaceutical industry.