Electrosynthesis of Aryliminophosphoranes in Continuous Flow

Rodrigo Costa e Silva, Clara Vega, Morgan Regnier, Luca Capaldo, Lars Wesenberg, Grace Lowe, Kleber Thiago de Oliveira, Timothy Noël

A practical electrochemical method for synthesizing aryliminophosphoranes from widely available nitro(hetero)arenes in a continuous-flow system is presented. The utilization of flow technology offers several advantages to our approach, including the elimination of the need for a supporting electrolyte and enhanced scalability. Our method demonstrates good tolerance towards various functional groups, with electron-deficient nitroarenes being particularly suitable for this strategy. In addition, we have demonstrated the versatility of aryliminophosphoranes as intermediates in synthesizing anilines, amines, and amides. To further enhance the utility of our approach, we have developed a telescoped method that utilizes a tube-in-tube setup for the in-situ production of isocyanates.

Press release - 30th May 2023

Sustainable syntheses for the production of fine chemicals

The international research network „MiEl“ aims to develop novel synthesis technologies that use renewable and sustainable electricity for the production of pharmaceuticals and other valuable chemicals.

Electrochemical synthesis pathways are an efficient use of renewable energies. In the research network „MiEl“ (Grant Agreement No. 101073003), led by the Fraunhofer Institute for Chemical Tech-nology ICT and funded by the Marie Sklodowska-Curie Program of the European Union, 12 international PhD students will develop electrochemical synthesis processes for mass production, applying concepts of microfluidic cells. To make the syntheses efficient and powerful, simulations and modelling will accompany the system development. The technologies will be developed for industrial applications in collaboration with relevant industry.

The special feature of this type of project is that the doctoral students will have the opportunity to be trained by an interdisciplinary European consortium of industrial companies and research organizations. The PhD students recruited by the industrial partners will complete research stays at the academic partners, while the PhD students at the academic institutions will complete secondments mainly in industry. All 12 doctoral candidates are linked together in a scientific program to solve interdisciplinary research questions in the very promising field of electrosynthesis. This creates a valuable network where academic know-how can be quickly transferred into applications for industry or society. The doctoral students will receive excellent training in both scientific, technical and soft skills like management or presentation techniques. Their new knowledge of research and development methods will be trained in practice applying the newly developed models, materials, and processes to develop new synthetic routes for fine chemicals and pharmaceuticals.