"Organic electrosynthesis is a promising technique of unmatched potential, that is however underexplored to this day. Generally applicable approaches to the subject are urgently needed and such innovations will only be possible in a highly interdisciplinary framework as MiEl project.
I strongly believe that the collaboration of a team of competent individuals with different backgrounds will be both highly beneficial to the field and fundamental for the further development of industrial applications. In this context, the aim is not only to develop useful application of the research, but also to make a significant impact in the field of electrosynthesis. "
Filippo Begal
MiEl Doctoral Candidate

About my academic career

About my thesis - Electro-organic synthesis of reactive intermediates

The interest of the project is focused on the design and development of organic electrosynthetic reactions in a micro flow setup.
Organic electrosynthesis is a discipline that only in recent time gained significant widespread interest. Its inherent ability to generate reactive intermediates is of primary interest for the discovery of novel organic reactions. At the same time, flow chemistry allows for reactions that are inherently safer due to the virtually absent accumulation of dangerous process intermediates, and the process can be subjected to a fine control of the conditions.

The objective of this project is to develop a set of rationally designed electrochemical reactions in a way to exploit the electrogenerated reactive intermediates and to easily allow for the transfer in flow reaction conditions.
The employment of non-aqueous solvents and controlled conditions is crucial to fully exploit the reactivity profiles of reactive intermediates, therefore it will represent a key approach to the research.

Several challenges will be addressed, such as the conditions for the electrogenerated reactive intermediate generation and utilization, the criteria for the transfer into flow condition and the implementation of process analytical technologies.
As case study for the project, the synthesis of different classes of target compound of known synthetic utility will be tackled, with the aim to demonstrate the potentiality of the method for industrial applications.

The general aim is therefore to gain knowledge about electrosynthetic capabilities and to develop processes that are safer, scalable, and more efficient thanks to the employment of micro flow electrochemical reactors.